SuperExactTest - Exact Test and Visualization of Multi-Set Intersections

Identification of sets of objects with shared features is a common operation in all disciplines. Analysis of intersections among multiple sets is fundamental for in-depth understanding of their complex relationships. This package implements a theoretical framework for efficient computation of statistical distributions of multi-set intersections based upon combinatorial theory, and provides multiple scalable techniques for visualizing the intersection statistics. The statistical algorithm behind this package was published in Wang et al. (2015) <doi:10.1038/srep16923>.

Last updated 1 years ago

intersectionsetstatisticsvisualization

7.45 score 27 stars 1 dependents 70 scripts 266 downloads

NetWeaver - Graphic Presentation of Complex Genomic and Network Data Analysis

Implements various simple function utilities and flexible pipelines to generate circular images for visualizing complex genomic and network data analysis features.

Last updated 2 years ago

4.75 score 4 stars 28 scripts 208 downloads

COMBAT - A Combined Association Test for Genes using Summary Statistics

Genome-wide association studies (GWAS) have been widely used for identifying common variants associated with complex diseases. Due to the small effect sizes of common variants, the power to detect individual risk variants is generally low. Complementary to SNP-level analysis, a variety of gene-based association tests have been proposed. However, the power of existing gene-based tests is often dependent on the underlying genetic models, and it is not known a priori which test is optimal. Here we proposed COMBined Association Test (COMBAT) to incorporate strengths from multiple existing gene-based tests, including VEGAS, GATES and simpleM. Compared to individual tests, COMBAT shows higher overall performance and robustness across a wide range of genetic models. The algorithm behind this method is described in Wang et al (2017) <doi:10.1534/genetics.117.300257>.

Last updated 3 years ago

3.70 score 7 scripts 285 downloads