Package: COMBAT 0.0.4
COMBAT: A Combined Association Test for Genes using Summary Statistics
Genome-wide association studies (GWAS) have been widely used for identifying common variants associated with complex diseases. Due to the small effect sizes of common variants, the power to detect individual risk variants is generally low. Complementary to SNP-level analysis, a variety of gene-based association tests have been proposed. However, the power of existing gene-based tests is often dependent on the underlying genetic models, and it is not known a priori which test is optimal. Here we proposed COMBined Association Test (COMBAT) to incorporate strengths from multiple existing gene-based tests, including VEGAS, GATES and simpleM. Compared to individual tests, COMBAT shows higher overall performance and robustness across a wide range of genetic models. The algorithm behind this method is described in Wang et al (2017) <doi:10.1534/genetics.117.300257>.
Authors:
COMBAT_0.0.4.tar.gz
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COMBAT.pdf |COMBAT.html✨
COMBAT/json (API)
# Install 'COMBAT' in R: |
install.packages('COMBAT', repos = c('https://mw201608.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/mw201608/combat/issues
Last updated 3 years agofrom:9479df64b9. Checks:8 OK. Indexed: yes.
Target | Result | Latest binary |
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Doc / Vignettes | OK | Feb 02 2025 |
R-4.5-win | OK | Feb 02 2025 |
R-4.5-mac | OK | Feb 02 2025 |
R-4.5-linux | OK | Feb 02 2025 |
R-4.4-win | OK | Feb 02 2025 |
R-4.4-mac | OK | Feb 02 2025 |
R-4.3-win | OK | Feb 02 2025 |
R-4.3-mac | OK | Feb 02 2025 |
Readme and manuals
Help Manual
Help page | Topics |
---|---|
A Combined Gene-based Association Test | COMBAT |
Extended Simes Procedure | ext_simes |
Calling Gene-based Association Tests | gates simpleM vegas |
Linkage Disequilibrium Estimate as Correlation | ld.Rsquare |